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Evidence is increasing that most addiction without exception is related to problems with the brain's reward center, specially the mesolimbic system. This section of the problem regulates reward responses in establishing food and sex, plus nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both whenever they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed pounds can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with fat loss and the those who go through it you need to err to the side of caution and let the FDA do its job and demand some study be done so that the public recognizes the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on their medications. Researchers found that participants taking this drug to get a year, lost weight within 4 weeks and have kept the extra weight off during the entire 56 weeks of the study. Contrave can be a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which are made up of several active ingredient, which may make them more potent and safer. Combo-pilling may be the newest fad or also the newest ahead under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular is the fact that at the time of right now there are no long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug may also raise hypertension and heartbeat, and must not be used in those with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high blood pressure levels, as well as by a person with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. Acamprosate also functions eliminate the need to drink by reducing the the cravings for having a drink. The major difference between Naltrexone and Acamprosate is always that Acamprosate is not yet accessible in the United States. While it has become widely studied in Europe the precise chemical reason that it works remains unknown. It is thought that it inhibits receptors in the brain which process glutamate, which essentially alters the way ones body reacts to alcohol intake. Several of the European research has shown a lot of promise with Acamprosate because some of the patients had an almost double effectiveness for staying sober.